The explorations of consciousness that started in the 1960s with early psychonauts’ attempts to articulate the psychedelic experience have now been rocketed into something entirely new with frontier AI models. Artists are using image and video models to express the ineffable frontiers of human experience, and biotech researchers are using large language models to calculate psychonauts’ “trip reports” and create novel altered states of consciousness that are now being tested in human trials. AI is now pushing the boundaries at the cutting edge of human experience.