Despite heightened awareness from media portrayals like "Painkiller" & "Dopesick," the opioid crisis persists, with more than 130 people dying daily from opioid-related overdoses. AI is transforming the fight against opioid misuse by detecting prescription irregularities, generating risk scores, analyzing patient behavior, & identifying suspicious prescribing patterns more quickly & accurately. This session explores the latest advancements in drug diversion intelligence & their critical role in empowering healthcare organizations to address the opioid epidemic through real-world applications.