In an era of flux and angst, certainty-centricity is alluring – and costly. We look to ultra-sure leaders and rely on synthetic minds that have no second thoughts. But a new science of uncertainty is upending our outdated notions of this mindset as weakness, revealing an unexpected path to human flourishing and planetary survival. Far from miring us in inertia, productive unsureness fuels agility, curiosity, resilience, and creativity, the skills most needed in volatile times. We’ll explore three key modes of uncertainty-in-action for 2025 and beyond, plus proven strategies for wielding this cogni-power to boost workflow, team performance, and personal well-being. Humanity stands on the cusp of a seismic shift in its approach to not-knowing. It’s not outrageous - and increasingly it’s necessary - to envision a future in which uncertainty can save humanity.