The rise of psychedelic medicine offers transformative potential but risks repeating past mistakes. Coca, a sacred Andean plant, is misunderstood in the West despite its traditional role as a source of energy, nutrition, and resilience. Its misuse highlights the need to honor indigenous knowledge and avoid exploitation. As psychedelics gain mainstream attention, ethical practices, equitable collaboration with Indigenous communities, and expanded research are essential to balance tradition, innovation, and respect for cultural and ecological roots.