Space-based nations cannot operate in a vacuum. The ability to harness civil and defense space capabilities alongside innovation is essential to maximize benefits and protect space for all humanity. The natural space environment comes with its own threats, congestion and increasing human threats. International partnerships and capabilities are needed to address these global challenges from the defense, commercial, and policy fronts. In this panel, global leaders will discuss the possibilities and challenges of collaborating across political boundaries to protect and navigate the new space era.