HBO’s “The Last of Us" captivated audiences with its gripping portrayal of a post-apocalyptic world ravaged by a fungal infection. While this scenario remains fictional, the threat of fungal infections to civilization is indeed a grim reality. This panel of infectious disease experts from industry, government, and academia, will explore real-life challenges posed by fungi, why fungal infections are becoming harder to treat, cross-resistance due to dual use of antifungals in both agriculture and medicine, and how our shared DNA with fungi makes it challenging to develop novel antifungals.