The next era of spatial computing and extended reality (XR) possess both great promise and unforeseen harms. As we navigate this exciting frontier, it’s our responsibility to address the need for thoughtful frameworks, designed from the bottom up to regulate virtual spaces and ensure they remain open, secure, trustworthy, and inclusive. This panel sheds light on the importance of fostering global conversations on how to build the responsible metaverse, inclusive of reliable safety, privacy, and security practices. The result will be a richer future with opportunity for all.