As the metaverse starts to take shape, much attention has been focused on the changes to business models and methods of monetization. But perhaps more significant, these immersive digital experiences will impact interpersonal relationships, identity and inclusion in profound ways. To create virtual worlds that people will want to participate in, designers must think about technology through the lens of the human condition. To achieve this, artists and technologists are working together to build new virtual worlds that leverage the full scope of human imagination and cognitive diversity. For this panel discussion, artists and technologists will share insights from their collaborations to explore some of the most confounding issues surrounding human experiences in the metaverse.