Worldwide ecosystems are declining at unprecedented rates, causing large scale species extinctions. Loss of these ecosystems is making communities more susceptible to ever-increasing natural disasters. Startups and small businesses supported by the U.S. National Science Foundation are creating cutting-edge technologies intended to support disaster resilience and ecosystem regeneration with the potential to improve the lives of millions. From machine learning to understand local and global ecosystems to robotic technology that can help replant lost reefs, startups are moving basic research out of the laboratory and into communities throughout the world.