How would you treat a kidney stone on the way to Mars? What if a climber developed an excruciating headache on Everest? How would you know whether a serious respiratory infection is viral or require antibiotics in a field clinic in Malawi? Providing quality healthcare in extreme environments presents challenges and opportunities. Medical technologies must be portable, minimally invasive, and easy to use and maintain. Devices must be robust and require only low power and consumables. Meds need to be very stable and safe for a long time. Healthcare solutions meeting these high standards have commercial advantages in driving revolutionary care for more traditional settings. By setting the bar high, we are driving border-less innovation in medicine, and creating new business opportunities.