NASA Great Observatories, including the Hubble Space Telescope, have supported new missions to Jupiter, Saturn, Ceres, and Pluto with outstanding imagery and science. NASA's upcoming infrared-optimized James Webb Space Telescope (JWST) offers scientists unique capabilities to measure changing conditions on planets, comets, and asteroids - and measure the atmospheres of extrasolar planets for key markers (ozone, carbon dioxide, and many others). The panel will discuss the discovery space for infrared space telescopes like JWST in Solar System and exoplanet science.