Born to a Seventh-day Adventist mother and Rastafarian father, Edwards received his musical calling at the age of seven, when he began singing in the church. Recognizing his talent, his parents introduced him to Mr. Wong, a record producer from Portmore, St. Catherine. "I did not take it seriously," said Edwards "My family members have always been carrying me to Portmore to see him, but I usually disappear. One day, they dropped me off at his studio and left me and it all began there."

Under the guidance of Mr. Wong and Earl Chinna Smith, Gyptian honed his sound, winning the 2004 Star Search talent competition at Kens Wild Flower Lounge in Portmore, earning him a spot at Sting 2004, dubbed the 'greatest one night reggae show on earth'.

The singer earned his nickname from his habit of tying a shirt around his head and twisting his chin hair like an Egyptian pharaoh.[citation needed] In 2005, he scored two hits, "Is There A Place" on the Seasons Riddim and "Serious Times".

Nominated for Best New Entertainer at the 2006 International Reggae and World Music Awards, the singer has been dominating the Jamaician charts with hits including "Is There a Place", "Beautiful Lady", and the chart-topping ballad, "Mama, Don't Cry".

On 12 September 2004, Gyptian released his first album on VP Records. On 12 December 2007, Gyptian, while in New York City, shot the music video, directed by Rhona Fox, for his new single, "I Can Feel Your Pain" (Cloud Nine Riddim) Produced by Jon FX. The song was the first to be confirmed to appear on his album I Can Feel Your Pain, which was released in 2008.

As of the end of May 2010, his single "Hold Yuh" had peaked at number 91 on the Billboard Hot 100, number 33 on the Billboard R&B/Hip-Hop Chart, number 6[1] on the Billboard Heatseekers Songs Chart and had been at the top of the Reggae Digital Songs chart for nine consecutive weeks.

In June, the song re-entered the Billboard Hot 100 and eventually reached a new peak of 77 on that chart, number 3 on the Heatseekers Songs chart, 31 on the Billboard R&B/Hip-Hop Chart, 63 on the Radio Songs chart and an astonishing peak of 28 on the Billboard Rhythmic Top 40, capitalising it crossover success. The song also peaked at number 1 on the Dancehall/Reggae fusion Charts of the Jamaica Weekly Music Charts for two consecutive weeks. In Canada it peaked at No. 69 on the Canadian Hot 100.The official remix for the song features rapper Nicki Minaj.It spent 29 weeks on the Billboard R&B/Hip-Hop Chart and 15 weeks on the Billboard Hot 100.

Gyptian had further chart success with his album Hold Yuh, which reached number 2 on Billboard's Reggae Albums Chart. The title track, "Hold Yuh", became a multi-chart hit worldwide. According to Billboard magazine, "not since Wayne Wonder's "No Letting Go" has an underground reggae artist garnered as much attention in the United States as Jamaica's own Gyptian."

The song also became popular in the UK, and was released there on 7 November by Ministry of Sound Recordings, in an EP which will include remixes by Shy FX, Major Lazerand Toddla T.

In October 2012 he released the SLR EP, which included three tracks from his forthcoming Sex, Love & Reggae album.[6] Sex, Love & Reggae was released in October 2013 and entered the Billboard Top Reggae Albums chart at number one.

His latest album, Nothing to Lose, is set for release in April 2015.