Computing interfaces are evolving rapidly. The mouse and keyboard are becoming passe. Voice recognition is getting much better, enabling new possibilities. Motion interfaces (think XBox Kinect) allow us to use our bodies, and motion, to drive ocmputing. But the ultimate interface is your brain- biology connected to technology, wetware connected to hardware. We'll take a brief look at the evolution of interfaces for a historical perspective, then discuss the potential and perils of biological computing.