As our world becomes more complex, it’s crucial to design systems that make life easier. Space presents some of the toughest challenges we face - its harsh environment, strict technical requirements, and emerging business opportunities. To advance the new space economy, we need to ensure astronauts and ground teams have effective and user-friendly solutions. By leveraging creativity and focusing on the human experience we can expand access, improve life in space for future crews, and support business growth as space technologies and partnerships continue to expand. This panel will explore how human-centric design leads to better outcomes for both humans and businesses, in space and on Earth.