Sisters focuses on two estranged siblings who are forced to confront each other as their comatose mother nears death. Andy, a self-centered failing actress, returns to her childhood home to find Emily, her older sister whose life is on hold while she cares for their dying mother. Tensions mount as they argue over whether or not to sell their mother's house, but when the two devise a game to divide up the belongings, hidden secrets come to light resulting in a well-intentioned, but ill-fated resolution.