The U.S. and sub-Saharan Africa may be miles apart in terms of economic resources and geography, but they share a disturbing legacy—health disparities caused by systemic racial and gender inequality. In the U.S., unequal access to quality healthcare results in poorer health outcomes in Black communities, including higher rates of maternal mortality, chronic diseases, and preventable deaths. In sub-Saharan Africa, gender inequalities and barriers to accessing healthcare contribute to the highest maternal mortality rates in the world, and young women disproportionately affected by HIV/AIDS. This conversation will examine the drivers of inequalities that affect healthcare in the U.S. and sub-Saharan Africa, the similarities and differences in the regions, and what we can do to address them.