The challenge of a changing labor market is already here. Between 60% and 70% of the activities performed today by humans will be replaced by machines. In Brazil’s largest state of São Paulo, the 21st largest economy in the world, the government sees this paradigm shift as an opportunity to address endemic social inequities and build a more efficient, sustainable economy for all. São Paulo is engaging a range of stakeholders, from tech entrepreneurs to creatives, to leverage public-private partnerships for an inclusive transition to a 21st century economy. A native of one of São Paulo’s marginalized neighborhoods who made it to Harvard, SP’s Secretary of Economic Development tells how she is walking the talk to guide the state’s economic transformation towards sustainable social equality.