Cannabinoids work differently in the elders. While people are afraid of neurological disturbance caused by Cannabis in the youngsters, it can actually heals an old man's brain. For instance, cognitive impairment in Alzheimer's disease models are reduced by activation of the cannabinoid receptors. Curiously, the mean age of regular medical Cannabis patients is above the 50’s, when the neurons become vulnerable due to senescence.
I will discuss original data linking the decline of the endogenous cannabinoids and the vulnerability of the aged brain. With this approach, we are developing a diagnostic marker for neurodegenerative diseases and dementias, already validated in a clinical sample of Alzheimer's patients.

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