The Scientific Method is a perfect paradigm for the creation of successful startups. It relies upon controlled experiments to validate predictions of market success. In university startups, what we call the "Scientific Startup Method" is widely practiced. The majority of globally important startups sprang from research universities and national labs. Is this hypothesis provable in the real world? Yes, the San Francisco Bay Area offers two world-class research universities (Stanford and Berkeley) and two National Research labs. The Scientific Method is the core of the Bay Area's vast startup success.