Your Life in Big Data: Drugs and the Environment
Sunday, March 15
3:30PM - 4:30PM
110 E 2nd St
Our exposome, like our genome, plays an instrumental role in our livelihood. The exposome is defined as the collection of all environmental exposures humans encounter from birth to death, including dietary nutrients, drugs, pollutants, bacteria, and viruses. These factors can alter our genetic predisposition for disease. Unlike our genomes, however, our exposomes are not predetermined. Our disease risk can be changed by modifying our exposome. Additionally, the exposome itself is made up of interactions, such as the way drugs interact to produce unwanted side effects or additional benefits.
In this two and a half hour long workshop, we begin to answer this question by introducing the concept of a “Personal Exposome Project”. We shall provide answers to what environmental exposures are and what the exposome concept is. We will show how how scientists – and now individuals – can search for exposures associated with disease. We will try to answer how the genome and exposome interact.
Chirag Patel’s long-term research goal is to address problems in human health and disease by developing computational and bioinformatics methods to reason over large-scale genomic and environmental...Show the rest
Chirag Patel’s long-term research goal is to address problems in human health and disease by developing computational and bioinformatics methods to reason over large-scale genomic and environmental information spanning molecules to populations. Chirag’s interests in computing began as a software engineer at Applied Biosystems, a biotechnology company that manufactured the first genome sequencers and wrote algorithms still in use in the devices today. Realizing that our genomes are just a small bit of the story in human disease after 8 years in the biotechnology industry, Chirag attended graduate school in biomedical informatics at Stanford University. During grad school, Chirag created the first “search engine” to search for environmental exposures associated with disease. Chirag is now starting his own laboratory at the Harvard Center for Biomedical Informatics under early investigator funding from the PhRMA Foundation and the NIH National Institutes of Environmental Health Sciences.Hide the rest
Dr. Nicholas Tatonetti is assistant professor of biomedical informatics in the Departments of Biomedical Informatics, Systems Biology, and Medicine at Columbia University. He received his PhD from ...Show the rest
Dr. Nicholas Tatonetti is assistant professor of biomedical informatics in the Departments of Biomedical Informatics, Systems Biology, and Medicine at Columbia University. He received his PhD from Stanford University where he focused on the development of novel computational methods for observational data mining. He applied these methods to drug safety surveillance where he discovered and validated new drug effects and interactions. His lab at Columbia is focused on expanding upon his previous work in detecting, explaining, and validating drug effects and drug interactions from large-scale observational data. Widely published in health data science, computational biology, and network analysis, Dr. Tatonetti is passionate about the integration of hospital data with high-dimensional biological data. He has been featured by the New York Times, Genome Web, and Science Careers. His work has been picked up by the mainstream and scientific media and generated thousands of news articles.Hide the rest